OncuraMultiple Myeloma21-day cycle8 effects documented
A three-drug combination for myeloma. The effect to watch most is nerve tingling in the hands/feet from bortezomib — report it early, as newer weekly under-the-skin dosing keeps it much lower. You'll take a blood thinner (often aspirin) to prevent clots, plus an antiviral to prevent shingles. Lenalidomide requires strict pregnancy prevention.
Get help straight away — this is true on any regimen, on any day.
A temperature of 100.4°F (38°C) or higher during treatment can mean a serious infection while your blood counts are low. Call your team or go to the ER — do not wait it out.
Also urgent: trouble breathing or chest pain · swelling of the face, lips or throat · new confusion or fainting · shaking chills · not being able to keep fluids down.
This is standing guidance shown to everyone. Nothing on this page is based on anything about you, and nobody is monitoring you.
One of the 8 entries below is marked provisional. They are shown because leaving them out would be its own distortion, but they have not yet been checked against the source document by a person, and they are not presented as authoritative. Every provisional entry is labelled where it appears.
Day 1 is the day of your infusion. These are the effects a retrievable document ties to a day range for this regimen — not a prediction about you.
Typically around days 11–21
A drop in infection-fighting white cells from lenalidomide. Your team checks counts and may adjust the dose or add a booster.
Call your team urgently: A temperature of 100.4°F (38.0°C) or higher — an emergency.
Typically around days 11–21
Drops in platelets (bruising/bleeding) and red cells (tiredness). Bortezomib's platelet dip is typically cyclical, recovering between cycles.
Call your team: Bleeding that won't stop, black/tarry stools, or new breathlessness.
These build with the number of doses, or are measured from when treatment started, so a cycle day would be the wrong shape for them. Each keeps the timing its own source states.
builds with dosing; can appear/worsen any time; may be permanent
Bortezomib's signature effect: numbness, tingling, or burning pain in the hands and feet. It builds with dosing and can become long-lasting or permanent, so tell your team at the first sign — dose changes help. Modern WEEKLY, under-the-skin dosing makes severe neuropathy much less likely (grade 3+ roughly 6% under-the-skin vs 15% into-the-vein).
Call your team: Numbness or pain that makes it hard to button clothes, walk, or feel the floor — report early.
any time; elevated throughout treatment
Lenalidomide (with dexamethasone and myeloma itself) raises the risk of clots in the legs or lungs — so you'll take a blood thinner, usually aspirin, to prevent them. Report leg swelling/pain or sudden breathlessness or chest pain at once.
Call your team urgently: Sudden breathlessness, chest pain, or a swollen, painful calf — emergency.
any time on treatment
Bortezomib raises the risk of a shingles flare (a painful blistering rash in a band), so you'll take a preventive antiviral, which greatly lowers the risk. Report any painful blistering rash early.
Call your team urgently: A painful blistering rash, especially near the eye — seek care.
Common loose stools. Late-onset lenalidomide diarrhea sometimes responds to a specific bile-acid medicine — mention it if it persists.
on dosing days; ongoing
On steroid days you may notice higher blood sugar, trouble sleeping, mood changes, and stomach irritation, plus added infection risk. Take steroids in the morning if advised, monitor glucose if diabetic, and don't stop them suddenly.
Lenalidomide causes severe birth defects and must never be taken during pregnancy. A strict prevention program applies: pregnancy testing and two reliable birth-control methods (or abstinence) during and for 4 weeks after treatment, for anyone who could become pregnant.