OncuraBrain - Glioblastoma28-day cycle6 effects documented
Oral chemotherapy (temozolomide) taken with radiation for glioblastoma, then in monthly 5-day courses. It's usually well tolerated — the key things monitored are blood counts (platelets especially, which can drop gradually) and nausea. You'll take a preventive antibiotic during radiation because the treatment lowers immune cells.
Get help straight away — this is true on any regimen, on any day.
A temperature of 100.4°F (38°C) or higher during treatment can mean a serious infection while your blood counts are low. Call your team or go to the ER — do not wait it out.
Also urgent: trouble breathing or chest pain · swelling of the face, lips or throat · new confusion or fainting · shaking chills · not being able to keep fluids down.
This is standing guidance shown to everyone. Nothing on this page is based on anything about you, and nobody is monitoring you.
No effect in this record carries a day window that a retrievable document supports for this regimen. That is a gap in the evidence, not a sign that nothing happens — the effects below are still what is reported.
These build with the number of doses, or are measured from when treatment started, so a cycle day would be the wrong shape for them. Each keeps the timing its own source states.
nadir ~days 21-28; can be delayed/cumulative
Temozolomide can lower platelets (bruising/bleeding), white cells, and red cells — platelets especially, sometimes in a delayed, cumulative way over cycles. Your team checks blood counts regularly. Watch for easy bruising or bleeding.
Call your team urgently: Bleeding that won't stop, black/tarry stools, or a fever of 100.4°F (38.0°C)+.
during/after the daily radiation phase
Daily temozolomide during radiation lowers immune cells and raises the risk of an unusual lung infection (PJP pneumonia), so you'll take a preventive antibiotic during that phase. Take it as directed and report fever, cough, or breathlessness.
Call your team urgently: Fever, cough, or breathlessness — contact your team.
Sickness in the first 24 hours is the "acute" phase and usually peaks 2-3 hours in; anything from 24 to 120 hours is the "delayed" phase.
Common but usually well controlled with anti-nausea medicine taken before the pills. Take temozolomide on an empty stomach at the same time each day as advised.
builds through radiation; peaks near the end
Tiredness is very common, driven by both the radiation and the chemo, and often peaks toward the end of the radiation phase before improving. Pace activities and rest.
Common, partly from anti-nausea medicines. Fluids, fiber, activity, and laxatives as advised help.
builds through radiation
Radiation causes hair thinning/loss and a skin reaction only in the treated area of the scalp, which builds through the course and usually recovers afterward (hair regrowth varies).