The same three medicines as dose-dense AC-T, given every 3 weeks. Low white cells peak about day 11 of the paclitaxel part.
AC×4 q3wk then paclitaxel q3wk. Nadir-based, days since infusion; paclitaxel nadir is later than AC.
Get help straight away — this is true on any regimen, on any day.
A temperature of 100.4°F (38°C) or higher during treatment can mean a
serious infection while your blood counts are low. Call your team or go to the ER — do not
wait it out.
Also urgent: trouble breathing or chest pain · swelling of the face, lips or throat ·
new confusion or fainting · shaking chills · not being able to keep fluids down.
This is standing guidance shown to everyone. Nothing on this page is based on anything
about you, and nobody is monitoring you.
Timed to the cycle
Day 1 is the day of your infusion. These are the effects a retrievable
document ties to a day range for this regimen — not a prediction about you.
Infusion reaction
During or just after an infusion
Paclitaxel can cause an allergic-type reaction during the infusion; premedication is given and you're watched closely.
Call your team urgently: Rash, trouble breathing, or swelling during/after an infusion — tell the team immediately.
severe in 2% · Timing is part of what this effect is · from Paclitaxel
Neutropenia
Typically around days 8–21
Low infection-fighting white cells, lowest about day 11 of the paclitaxel part.
Call your team urgently: A temperature of 100.4°F (38.0°C) or higher — an emergency.
reported by about 50% (<500) of people; severe in 15% · Timing from the manufacturer’s prescribing information · from Doxorubicin, Cyclophosphamide, Paclitaxel
Hair loss
Typically around days 14–21
Near-universal; grows back after treatment.
Call your team: Scalp pain, redness, or inflammation.
reported by about 100% of people · Timing from a drug-monograph reference · from Doxorubicin, Cyclophosphamide, Paclitaxel
Not tied to a cycle day
These build with the number of doses, or are measured from when treatment started, so a cycle day would be the wrong shape for them. Each keeps the timing its own source states.
Neuropathy
Builds up with the number of doses rather than arriving on a particular day of the cycle. Tell your team early — adjusting the dose is what helps most.
Tingling or numbness in the hands and feet; builds over the paclitaxel doses and is dose-related.
Call your team: New or worsening numbness, or trouble with buttons/zippers.
reported by about 20% of people; severe in 3% · Timing from the manufacturer’s prescribing information · from Paclitaxel
Cardiotoxicity
Most heart effects that appear do so within the first year. They are checked by scan every few months during treatment, not by cycle day.
Low heart-muscle risk at this total anthracycline dose; monitored with heart scans.
Call your team: New shortness of breath, leg/ankle swelling, or a racing/irregular heartbeat.
severe in <1% · Timing from a clinical guideline · from Doxorubicin
Where this comes from
S1. Paclitaxel (Taxol) FDA prescribing information (adjuvant AC→paclitaxel, CALGB 9344) — FDA label
S2. Sparano JA, ECOG E1199 (2008) — PMID 18420499
Timing windows on this page rest on:
Taxol (paclitaxel) FDA prescribing information — “Neutrophil nadirs occurred at a median of 11 days” source
Definitional — an infusion reaction is one that occurs during or shortly after the infusion — “The timing is part of what the term denotes; there is no empirical claim here to source.”
BC Cancer Drug Manual — paclitaxel — “usually complete, generally occurs 14-21 days after administration of paclitaxel; onset sudden, often occurring in a single day” source
American College of Cardiology — anthracycline cardiotoxicity (2024) — “acutely (<1% of cases), early-onset (within first year, 98% of cases), or late-onset (>1 year after treatment)” source
A window appears here only where a retrievable document ties it to a drug in
this regimen. Where nothing could be found, the window was removed rather than estimated —
so a missing time is an honest gap, not an oversight.
Oncura